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While safe at therapeutic doses of up to 4 g per day for adults, APAP overdoses, either accidental or intentional, are one of the leading causes of acute liver failure in the United States [33]

SAM serves as a major methyl group donor in numerous methylation reactions across various tissues, particularly within the central nervous system, working in reactions that form phospholipids and biogenic amines (65, 67)

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Poor Metabolic Health When blood sugar levels are inconsistent, the body produces more free radicals